Invited Speaker Asia-Pacific Vaccine and Immunotherapy Congress 2024

Host-directed Therapies for Respiratory Infections (#23)

Amit Singhal 1
  1. A*STAR Infectious Diseases Labs, Singapore

Respiratory infectious diseases such as tuberculosis and COVID-19 are the leading cause of morbidity and mortality worldwide. It is known that immunopathological changes among the patients are complex and may associate with disease severity. We performed genome-wide epigenomic approaches, Histone acetylation (HWAS) and DNA methylation (WGBS), to investigate the heterogeneous epigenetic networks in longitudinal blood samples from TB and COVID-19 patients. In this talk I will discuss the data from these investigations which has resulted in the identification of novel immune factors of host defense, those can be targeted to design host-directed therapies.